HomeMy WebLinkAboutThe Citizen, 2018-07-19, Page 9THE CITIZEN, THURSDAY, JULY 19, 2018. PAGE 9.
Smiths receive diagnosis through genetic testing
News at last
Colton Smith, centre, has been living his life under a cloud of mysterious symptoms that have
greatly impacted his life. For over a decade he had been battling these symptoms with no end
in sight, but the family now has some guidance thanks to a trip to the Mayo Clinic and then
further research at the London Health Sciences Centre. Colton has now been diagnosed with
Gluts Deficiency Syndrome, but through a strict diet, he will be able to live a long and fruitful
life, which makes him and his parents Jamie and Joanne very happy. (File photo)
By Shawn Loughlin
The Citizen
Nearly a year to the day that
Blyth's Colton Smith's story was
first reported on, his family has
received a positive diagnosis that
will see the teenager live a long and
fruitful life.
Colton, now 14 years old, has been
struggling with a condition that first
began to show symptoms when he
was three years old. Over the last 10
years, his condition has left scores of
doctors baffled and his health
continued to deteriorate while his
condition remained undiagnosed.
However, after a trip to the Mayo
Clinic in the U.S., Smith's condition
has now been diagnosed as a rare
genetic condition that only affects
approximately 500 people across the
globe.
Smith has Glutl Deficiency
Syndrome, which is the result of a
mutation in the SLC2A1 gene,
which regulates the transportation of
glucose to the brain. With sugar
being the main source of energy
across the blood -brain barrier, for
years, Smith's brain hasn't been
getting the glucose it needs from the
food he eats.
While there is no cure for the
condition, it can be managed
through the strict Ketogenic Diet, a
high-fat, moderate -protein and low -
carbohydrate diet. This diet will
replace glucose with ketones and
provide Smith with fuel that his
body is able to use.
If Smith sticks to the diet, his
health will remain as it is and he will
be able to live a long, fruitful life.
Colton's father Jamie says it's
great news, especially since many of
the conditions that were being
considered last year suggested a
high mortality rate. To be able to
discuss Colton having children and
how his condition will affect him
decades down the road is a good
feeling.
The difficulty will be, Jamie said,
for Colton to understand just how
important it is that he adheres to his
new diet, especially now that Colton
is in high school. Weeks of healthy
eating and progress through a
positive diet, Jamie said, could be
undone with one can of pop or some
junk food from the cafeteria.
He added that it's tough to explain
to a teenager that he can't have a
hamburger or candy with his friends,
but that it's essential for his long-
term health.
Last year, the Smiths went public
with their son's condition and the
community came to their aid, raising
thousands of dollars to help them
travel to the Mayo Clinic.
Jamie said that the doctor at the
Mayo Clinic was "bang -on" with his
diagnosis, identifying Glutl
Deficiency Syndrome during their
first two-hour meeting at the clinic.
However, the doctor explained that
the genetic testing and treatment
would be too cost -prohibitive at the
Mayo Clinic and advised that they
return to Canada, but he provided a
road map for them to diagnose
Colton's illness here at home.
Through testing at the London
Health Sciences Centre, they found
the deficient gene several months
ago through research, but had to wait
for confirmation through a clinical
trial.
This week the Smiths were due to
meet with their neurologist once
again in London for their next steps,
which will include meeting with a
dietician regularly over the course of
the next year.
Jamie says that if Colton's
condition had been diagnosed when
he was a young child, perhaps he
would have been able to live a
normal life from birth. However, the
physical and mental challenges that
he's faced over the past 10 years as a
result of his condition are now here
to stay. While his condition won't
get any worse if he adheres to the
Ketogenic Diet, Jamie said, Colton
won't get any better either.
The diagnosis comes after a
decade of frustration, grief and
sadness for the Smiths, who had to
watch their son struggle with a
condition that no one knew how to
treat.
When he was three years old and
fell for the first time and couldn't get
up, doctors said he simply had water
in his ear and that his temporary loss
of balance would pass in time.
When it happened again a week
later, this time Colton's fall was
dismissed as the actions of a clumsy
toddler. However, Colton's parents,
Continued on page 19
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